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MaxCyte provides regular updates on scalable transfection of ion channels, GPCRs, and other targets for cell-based assays. The MaxCyte® STX™ Scalable Transient Transfection System can co-transfect up to 1x10¹⁰ cells, including primary cells and stem cells, in less than thirty minutes with any combination of DNA, mRNA, siRNA or proteins.

The MaxCyte® STX™ Scalable Transfection System can help you develop assays faster, design and conduct more physiologically relevant assays, and improve the productivity of your laboratory. Increased productivity in drug discovery campaigns can increase your likelihood of finding successful drug candidates.

Please contact us if you would like additional information about a demonstration of the MaxCyte® STX™ Scalable Transfection System in your laboratory. 

Developing Assays for GPCR Screening with Transiently Transfected Cells Using the MaxCyte® STX™ System. MaxCyte provides a case study of cell-based assay development for screening GPCRs using HEK 293 cells transiently transfected with a M1 muscarinic acetylcholine receptor expression plasmid and analyzed using the FLIPRTETRA®system. Click here to download the Application Note. Developing a Luciferase-Based NF-kB Reporter Assay with Transiently Transfected HEK 293 Cells. In this case study, MaxCyte demonstrates that HEK 293 cells transiently transfected wtih a NF-kB responsive luciferase reporter plasmid exhibit robust, consistent and dose-dependent luciferase expression in response to TNF-alpha stimulation. Click here to download the Application Note.
	Rapid, Automated Development of Cell-Based Assays for Screening GPCRs, Ion Channels and other Target Molecules Using The MaxCyte® STX™ Scalable Transfection System. To demonstrate utility of the MaxCyte® STX™ technology for  cell-based assay development, HEK 293 and CHO cells were transfected with plasmid DNA encoding GPCRs, ion channels and reporter molecules.  MaxCyte  STX Users tested the transiently transfected cells in assay platforms that are commonly used for high throughput screening, including  automated calcium flux , electrophysiology and  high content screening assays. Cells transfected using the MaxCyte STX  performed comparably to stable cell lines in assay platforms.  This poster was presented at the MipTec meeting in Basel, Switzerland, on October 14, 2009. Click here to download the poster.