CAR Therapies

Overview

MaxCyte is an early stage drug development company. MaxCyte has developed a novel and proprietary platform for next-generation chimeric antigen receptor (CAR)-engineered cell therapies as well as our own novel CAR therapies

Our CARMA™ platform provides several unique attributes versus existing autologous CAR-T products and platforms.

First, MaxCyte’s CARMA platform offers the potential to deliver therapy to the patient in a fraction of the time with less complexity of other autologous CAR-T products. This is due to a more streamlined manufacturing process without the complexity of virus-based products.

Second, Maxcyte’s unique CAR autologous cell therapies are differentiated from traditional CAR therapy by our use of human messenger RNA (mRNA) to engineer the immune cells that are delivered back into a patient, without the need for a viral component. Our platform provides for transient expression, as shown in preclinical studies, which is designed to control the traditional adverse events seen with other CAR therapies.

We will study our first CAR drug candidate in mesothelin-expressing tumors. This product candidate, MCY-M11, employs repeat infusions of mesothelin-specific human mRNA CAR-transfected into PBMCs (peripheral blood mononuclear cells) to permit “controlled persistence.” Early non-clinical testing has provided preliminary evidence of the anti-tumor activity of this drug.

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